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Assay Detail

CHEMBL893095

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Functional
Antipromastigote activity against Leishmania infantum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania infantum (CHEMBL612848)
Type ORGANISM
Organism Leishmania infantum

Publication

Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.
Di Giorgio C, Shimi K, Boyer G, Delmas F, Galy JP.
Eur J Med Chem (2007) 42 : 1277 -1284
PubMed 17418916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.26 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244684 1 6.96
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.42
CHEMBL55400 PROFLAVINE 2.0 1 5.89
CHEMBL244685 1 5.77
CHEMBL244308 1 5.37
CHEMBL244686 1 5.32
CHEMBL244122 1 4.94
CHEMBL244121 1 4.79
CHEMBL244120 1 4.33
CHEMBL244123 1 4.06
CHEMBL243903 1 4.04
CHEMBL244501 1 -
CHEMBL397456 1 -
CHEMBL397455 1 -
CHEMBL428219 1 -
CHEMBL244683 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244684 IC50 = 110.0 nM 6.96
CHEMBL267345 AMPHOTERICIN B IC50 = 380.0 nM 6.42
CHEMBL55400 PROFLAVINE IC50 = 1300.0 nM 5.89
CHEMBL244685 IC50 = 1700.0 nM 5.77
CHEMBL244308 IC50 = 4310.0 nM 5.37
CHEMBL244686 IC50 = 4800.0 nM 5.32
CHEMBL244122 IC50 = 11500.0 nM 4.94
CHEMBL244121 IC50 = 16100.0 nM 4.79
CHEMBL244120 IC50 = 46700.0 nM 4.33
CHEMBL244123 IC50 = 86900.0 nM 4.06
CHEMBL243903 IC50 = 90800.0 nM 4.04
CHEMBL244501 IC50 = 202900.0 nM -
CHEMBL397456 IC50 = 132700.0 nM -
CHEMBL397455 IC50 = 186200.0 nM -
CHEMBL428219 IC50 = 159800.0 nM -
CHEMBL244683 IC50 = 341500.0 nM -