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Assay Detail

CHEMBL893097

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Functional
Antiamastigote activity against Leishmania infantum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania infantum (CHEMBL612848)
Type ORGANISM
Organism Leishmania infantum

Publication

Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.
Di Giorgio C, Shimi K, Boyer G, Delmas F, Galy JP.
Eur J Med Chem (2007) 42 : 1277 -1284
PubMed 17418916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.07 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244685 1 7.52
CHEMBL55400 PROFLAVINE 2.0 1 6.92
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.85
CHEMBL244684 1 6.70
CHEMBL397456 1 6.17
CHEMBL244121 1 6.10
CHEMBL244686 1 5.96
CHEMBL244308 1 5.96
CHEMBL244501 1 5.89
CHEMBL244122 1 5.54
CHEMBL244683 1 5.35
CHEMBL428219 1 5.11
CHEMBL244120 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244685 IC50 = 30.0 nM 7.52
CHEMBL55400 PROFLAVINE IC50 = 120.0 nM 6.92
CHEMBL267345 AMPHOTERICIN B IC50 = 140.0 nM 6.85
CHEMBL244684 IC50 = 200.0 nM 6.70
CHEMBL397456 IC50 = 670.0 nM 6.17
CHEMBL244121 IC50 = 800.0 nM 6.10
CHEMBL244686 IC50 = 1100.0 nM 5.96
CHEMBL244308 IC50 = 1100.0 nM 5.96
CHEMBL244501 IC50 = 1300.0 nM 5.89
CHEMBL244122 IC50 = 2900.0 nM 5.54
CHEMBL244683 IC50 = 4500.0 nM 5.35
CHEMBL428219 IC50 = 7700.0 nM 5.11
CHEMBL244120 IC50 = 12800.0 nM 4.89