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Assay Detail

CHEMBL893106

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Physicochemical
Distribution coefficient, log D at pH 7.4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Physicochemical
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Feng Z, Mohapatra S, Klimko PG, Hellberg MR, May JA, Kelly C, Williams G, McLaughlin MA, Sharif NA.
Bioorg Med Chem Lett (2007) 17 : 2998 -3002
PubMed 17419053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 7 9.24 10.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL397321 1 10.02
CHEMBL234464 1 9.80
CHEMBL234837 1 9.66
CHEMBL232995 1 9.51
CHEMBL134519 1 8.56
CHEMBL391196 1 8.56
CHEMBL234682 1 8.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL397321 EC50 = 0.096 nM 10.02
CHEMBL234464 EC50 = 0.16 nM 9.80
CHEMBL234837 EC50 = 0.22 nM 9.66
CHEMBL232995 EC50 = 0.31 nM 9.51
CHEMBL134519 EC50 = 2.72 nM 8.56
CHEMBL391196 EC50 = 2.72 nM 8.56
CHEMBL234682 EC50 = 2.92 nM 8.54