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Assay Detail

CHEMBL893116

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]LSD from human 5HT7 in sf9 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel aminoethylbiphenyls as 5-HT7 receptor ligands.
Paillet-Loilier M, Fabis F, Lepailleur A, Bureau R, Butt-Gueulle S, Dauphin F, Lesnard A, Delarue C, Vaudry H, Rault S.
Bioorg Med Chem Lett (2007) 17 : 3018 -3022
PubMed 17419056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 8.12 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL177064 1 8.33
CHEMBL181874 1 8.27
CHEMBL234881 1 8.21
CHEMBL234885 1 8.12
CHEMBL395870 1 8.12
CHEMBL232792 1 8.08
CHEMBL232791 1 8.07
CHEMBL368044 1 7.75
CHEMBL234886 1 -
CHEMBL234882 1 -
CHEMBL397614 1 -
CHEMBL234883 1 -
CHEMBL234884 1 -
CHEMBL397615 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL177064 Ki = 4.7 nM 8.33
CHEMBL181874 Ki = 5.4 nM 8.27
CHEMBL234881 Ki = 6.2 nM 8.21
CHEMBL234885 Ki = 7.5 nM 8.12
CHEMBL395870 Ki = 7.6 nM 8.12
CHEMBL232792 Ki = 8.4 nM 8.08
CHEMBL232791 Ki = 8.6 nM 8.07
CHEMBL368044 Ki = 18.0 nM 7.75
CHEMBL234886 Ki - -
CHEMBL234882 Ki - -
CHEMBL397614 Ki - -
CHEMBL234883 Ki - -
CHEMBL234884 Ki - -
CHEMBL397615 Ki - -