Assay Detail
Functional
CHEMBL893247
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Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding after 60 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.10 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 9.72 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.89 |
| CHEMBL428038 | — | — | 1 | 8.08 |
| CHEMBL242968 | — | — | 1 | 7.48 |
| CHEMBL290543 | — | — | 1 | 7.34 |
| CHEMBL394573 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL301160 | BUTORPHAN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL428038 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL242968 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL290543 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL394573 | — | EC50 | = | 87.0 | nM | 7.06 |