Assay Detail
Binding
CHEMBL893352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI55 from human NET expressed in COS1 cell membrane
50
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 4.93 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | -1.0 | 1 | 7.47 |
| CHEMBL388257 | — | — | 1 | 6.57 |
| CHEMBL215988 | — | — | 1 | 6.07 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.05 |
| CHEMBL242920 | — | — | 1 | 5.64 |
| CHEMBL243141 | — | — | 1 | 5.60 |
| CHEMBL397490 | — | — | 2 | 5.41 |
| CHEMBL396754 | — | — | 1 | 5.00 |
| CHEMBL245061 | — | — | 1 | 4.96 |
| CHEMBL232299 | — | — | 1 | 4.89 |
| CHEMBL395910 | — | — | 1 | 4.85 |
| CHEMBL233088 | — | — | 1 | 4.82 |
| CHEMBL243204 | — | — | 1 | 4.45 |
| CHEMBL388255 | — | — | 1 | 4.44 |
| CHEMBL396082 | — | — | 1 | 4.41 |
| CHEMBL103936 | — | — | 1 | 4.33 |
| CHEMBL231684 | — | — | 1 | 4.29 |
| CHEMBL232663 | — | — | 1 | 4.21 |
| CHEMBL434959 | — | — | 1 | 4.17 |
| CHEMBL232068 | — | — | 1 | 4.09 |
| CHEMBL398009 | — | — | 1 | 4.08 |
| CHEMBL396318 | — | — | 1 | 4.07 |
| CHEMBL234379 | — | — | 1 | 4.03 |
| CHEMBL233532 | — | — | 1 | - |
| CHEMBL397787 | — | — | 1 | - |
| CHEMBL442234 | — | — | 1 | - |
| CHEMBL394089 | — | — | 1 | - |
| CHEMBL394373 | — | — | 1 | - |
| CHEMBL393701 | — | — | 1 | - |
| CHEMBL233530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL388257 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL215988 | — | Ki | = | 855.0 | nM | 6.07 |
| CHEMBL370805 | COCAINE | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL242920 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL243141 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL397490 | — | Ki | = | 3910.0 | nM | 5.41 |
| CHEMBL396754 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL245061 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL232299 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL395910 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL233088 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL243204 | — | Ki | = | 35200.0 | nM | 4.45 |
| CHEMBL388255 | — | Ki | = | 36300.0 | nM | 4.44 |
| CHEMBL396082 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL397490 | — | Ki | = | 41600.0 | nM | 4.38 |
| CHEMBL103936 | — | Ki | = | 46700.0 | nM | 4.33 |
| CHEMBL231684 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL232663 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL434959 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL232068 | — | Ki | = | 81000.0 | nM | 4.09 |
| CHEMBL398009 | — | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL396318 | — | Ki | = | 85000.0 | nM | 4.07 |
| CHEMBL234379 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL234127 | — | Ki | = | 2500000.0 | nM | - |
| CHEMBL397520 | — | Ki | = | 2540000.0 | nM | - |
| CHEMBL232070 | — | Ki | = | 1100000.0 | nM | - |
| CHEMBL232069 | — | Ki | = | 215000.0 | nM | - |
| CHEMBL394585 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL232870 | — | Ki | = | 993000.0 | nM | - |
| CHEMBL232675 | — | Ki | = | 111000.0 | nM | - |
| CHEMBL232674 | — | Ki | = | 1318000.0 | nM | - |
| CHEMBL232867 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL232866 | — | Ki | = | 2884000.0 | nM | - |
| CHEMBL396083 | — | Ki | = | 789000.0 | nM | - |
| CHEMBL232672 | — | Ki | = | 550000.0 | nM | - |
| CHEMBL232671 | — | Ki | = | 470000.0 | nM | - |
| CHEMBL234128 | — | Ki | = | 2110000.0 | nM | - |
| CHEMBL438321 | — | Ki | = | 2020000.0 | nM | - |
| CHEMBL395649 | — | Ki | = | 675000.0 | nM | - |
| CHEMBL232879 | — | Ki | = | 121000.0 | nM | - |
| CHEMBL232498 | — | Ki | = | 255000.0 | nM | - |
| CHEMBL231858 | — | Ki | = | 339000.0 | nM | - |
| CHEMBL233532 | — | Ki | = | 658000.0 | nM | - |
| CHEMBL397787 | — | Ki | - | — | - | |
| CHEMBL394089 | — | Ki | = | 675000.0 | nM | - |
| CHEMBL442234 | — | Ki | = | 719000.0 | nM | - |
| CHEMBL233530 | — | Ki | = | 1360000.0 | nM | - |
| CHEMBL393701 | — | Ki | = | 991000.0 | nM | - |
| CHEMBL394373 | — | Ki | = | 439000.0 | nM | - |