Assay Detail
Functional
CHEMBL893355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membrane
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.51 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | -1.0 | 1 | 8.00 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.74 |
| CHEMBL232299 | — | — | 1 | 5.41 |
| CHEMBL233088 | — | — | 1 | 5.33 |
| CHEMBL395910 | — | — | 1 | 5.31 |
| CHEMBL232068 | — | — | 1 | 5.00 |
| CHEMBL398009 | — | — | 1 | 4.70 |
| CHEMBL396082 | — | — | 1 | 4.58 |
| CHEMBL245061 | — | — | 1 | 4.55 |
| CHEMBL232663 | — | — | 1 | - |
| CHEMBL232879 | — | — | 1 | - |
| CHEMBL396318 | — | — | 1 | - |
| CHEMBL434959 | — | — | 1 | - |
| CHEMBL103936 | — | — | 1 | - |
| CHEMBL394585 | — | — | 1 | - |
| CHEMBL232671 | — | — | 1 | - |
| CHEMBL232672 | — | — | 1 | - |
| CHEMBL232867 | — | — | 1 | - |
| CHEMBL232674 | — | — | 1 | - |
| CHEMBL396083 | — | — | 1 | - |
| CHEMBL232866 | — | — | 1 | - |
| CHEMBL397787 | — | — | 1 | - |
| CHEMBL232675 | — | — | 1 | - |
| CHEMBL232069 | — | — | 1 | - |
| CHEMBL232070 | — | — | 1 | - |
| CHEMBL397520 | — | — | 1 | - |
| CHEMBL234127 | — | — | 1 | - |
| CHEMBL234128 | — | — | 1 | - |
| CHEMBL232498 | — | — | 1 | - |
| CHEMBL438321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL370805 | COCAINE | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL232299 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL233088 | — | Ki | = | 4720.0 | nM | 5.33 |
| CHEMBL395910 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL232068 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL398009 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL396082 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL245061 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL232879 | — | Ki | - | — | - | |
| CHEMBL395649 | — | Ki | = | 499000.0 | nM | - |
| CHEMBL396318 | — | Ki | - | — | - | |
| CHEMBL434959 | — | Ki | - | — | - | |
| CHEMBL103936 | — | Ki | - | — | - | |
| CHEMBL394585 | — | Ki | = | 178000.0 | nM | - |
| CHEMBL232671 | — | Ki | = | 285000.0 | nM | - |
| CHEMBL232672 | — | Ki | = | 1390000.0 | nM | - |
| CHEMBL232867 | — | Ki | = | 646000.0 | nM | - |
| CHEMBL232674 | — | Ki | = | 247000.0 | nM | - |
| CHEMBL232870 | — | Ki | = | 314000.0 | nM | - |
| CHEMBL231858 | — | Ki | = | 871000.0 | nM | - |
| CHEMBL232663 | — | Ki | - | — | - | |
| CHEMBL396083 | — | Ki | - | — | - | |
| CHEMBL232866 | — | Ki | - | — | - | |
| CHEMBL397787 | — | Ki | - | — | - | |
| CHEMBL232675 | — | Ki | - | — | - | |
| CHEMBL232069 | — | Ki | - | — | - | |
| CHEMBL232070 | — | Ki | - | — | - | |
| CHEMBL397520 | — | Ki | - | — | - | |
| CHEMBL234127 | — | Ki | - | — | - | |
| CHEMBL234128 | — | Ki | - | — | - | |
| CHEMBL232498 | — | Ki | - | — | - | |
| CHEMBL438321 | — | Ki | - | — | - |