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Assay Detail

CHEMBL893371

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]LTB4 from LTB4 receptor in guinea pig spleen membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Spleen
Subcellular Membrane
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Leukotriene B4 receptor (CHEMBL2095160)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Antileukotrienic N-arylethyl-2-arylacetamides in the treatment of ulcerative colitis.
Junek R, Brůnová B, Kverka M, Panajotová V, Jandera A, Kuchar M.
Eur J Med Chem (2007) 42 : 1084 -1094
PubMed 17448575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.45 6.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL241946 1 6.18
CHEMBL241945 1 5.96
CHEMBL242574 1 5.92
CHEMBL242157 1 5.77
CHEMBL390870 1 5.72
CHEMBL242369 1 5.62
CHEMBL242366 1 5.33
CHEMBL390458 1 5.07
CHEMBL242365 1 4.75
CHEMBL242367 1 4.17
CHEMBL244274 1 -
CHEMBL242158 1 -
CHEMBL244478 1 -
CHEMBL93 ZILEUTON 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL241946 IC50 = 660.0 nM 6.18
CHEMBL241945 IC50 = 1100.0 nM 5.96
CHEMBL242574 IC50 = 1200.0 nM 5.92
CHEMBL242157 IC50 = 1700.0 nM 5.77
CHEMBL390870 IC50 = 1900.0 nM 5.72
CHEMBL242369 IC50 = 2400.0 nM 5.62
CHEMBL242366 IC50 = 4700.0 nM 5.33
CHEMBL390458 IC50 = 8600.0 nM 5.07
CHEMBL242365 IC50 = 18000.0 nM 4.75
CHEMBL242367 IC50 = 67000.0 nM 4.17
CHEMBL244274 IC50 - -
CHEMBL242158 IC50 - -
CHEMBL244478 IC50 - -
CHEMBL93 ZILEUTON IC50 > 100000.0 nM -