Assay Detail
Functional
CHEMBL893544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of nitric oxide formation in human A172 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A 172 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.52 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232827 | — | — | 1 | 8.05 |
| CHEMBL233031 | — | — | 1 | 8.00 |
| CHEMBL233032 | — | — | 1 | 7.28 |
| CHEMBL232825 | — | — | 1 | 7.24 |
| CHEMBL388880 | — | — | 1 | 7.11 |
| CHEMBL233236 | — | — | 1 | 7.00 |
| CHEMBL232255 | — | — | 1 | 6.62 |
| CHEMBL388881 | — | — | 1 | 6.60 |
| CHEMBL232819 | — | — | 1 | 6.19 |
| CHEMBL396273 | — | — | 1 | 5.92 |
| CHEMBL232818 | — | — | 1 | 5.82 |
| CHEMBL233030 | — | — | 1 | 5.80 |
| CHEMBL233441 | — | — | 1 | 5.80 |
| CHEMBL232826 | — | — | 1 | 5.77 |
| CHEMBL395498 | — | — | 1 | 5.75 |
| CHEMBL388205 | — | — | 1 | 5.38 |
| CHEMBL233235 | — | — | 1 | - |
| CHEMBL232422 | — | — | 1 | - |
| CHEMBL388417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232827 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL233031 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL233032 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL232825 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL388880 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL233236 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL232255 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL388881 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL232819 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL396273 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL232818 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL233030 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL233441 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL232826 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL395498 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL388205 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL233235 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL232422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388417 | — | IC50 | > | 10000.0 | nM | - |