Assay Detail
Binding
CHEMBL893568
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Inhibition of human recombinant CA9 after 15 mins by CO2 hydration stopped flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.97 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390035 | — | — | 1 | 8.00 |
| CHEMBL395734 | — | — | 1 | 7.96 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL395981 | — | — | 1 | 7.12 |
| CHEMBL232616 | — | — | 1 | 7.09 |
| CHEMBL233019 | — | — | 1 | 6.96 |
| CHEMBL232816 | — | — | 1 | 6.87 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.80 |
| CHEMBL232617 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390035 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL395734 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL395981 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL232616 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL233019 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL232816 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1590.0 | nM | 5.80 |
| CHEMBL232617 | — | Ki | = | 4500.0 | nM | 5.35 |