Assay Detail
Binding
CHEMBL893722
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Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234705 | — | — | 1 | 7.10 |
| CHEMBL390432 | — | — | 1 | 7.01 |
| CHEMBL234706 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234705 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL390432 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL234706 | — | IC50 | = | 290.0 | nM | 6.54 |