Assay Detail
Functional
CHEMBL893776
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Inhibition of fMLP-induced elastase release from human PMN cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PMN |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.41 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232419 | — | — | 1 | 6.72 |
| CHEMBL396761 | — | — | 1 | 6.42 |
| CHEMBL205654 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232419 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL396761 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL205654 | — | IC50 | = | 790.0 | nM | 6.10 |