Assay Detail
Binding
CHEMBL894021
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Inhibition of mouse recombinant MetAP2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243303 | — | — | 1 | 8.70 |
| CHEMBL444369 | — | — | 1 | 8.30 |
| CHEMBL230005 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243303 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL444369 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL230005 | — | Ki | = | 20.0 | nM | 7.70 |