Assay Detail
Binding
CHEMBL894075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR K145R mutant /5HT3A receptor in tsA201 cells
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | tsA201 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.60 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | — | 2 | 8.37 |
| CHEMBL229998 | — | — | 2 | 7.24 |
| CHEMBL395727 | — | — | 2 | 6.37 |
| CHEMBL231056 | — | — | 2 | 6.18 |
| CHEMBL415568 | — | — | 2 | 6.13 |
| CHEMBL382243 | — | — | 2 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL510275 | METHYLLYCACONITINE | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL229998 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL229998 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL395727 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL395727 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL231056 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL231056 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL415568 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL415568 | — | Ki | = | 741.31 | nM | 6.13 |
| CHEMBL382243 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL382243 | — | Ki | = | 5248.07 | nM | 5.28 |