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Assay Detail

CHEMBL894267

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV 1b NS5B delta21 RNA dependent RNA polymerase by enzymatic assay
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones.
Li H, Linton A, Tatlock J, Gonzalez J, Borchardt A, Abreo M, Jewell T, Patel L, Drowns M, Ludlum S, Goble M, Yang M, Blazel J, Rahavendran R, Skor H, Shi S, Lewis C, Fuhrman S.
J Med Chem (2007) 50 : 3969 -3972
PubMed 17658778 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.87 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL230744 3 9.00
CHEMBL230743 1 8.70
CHEMBL230635 1 8.40
CHEMBL390856 1 7.82
CHEMBL397464 1 7.77
CHEMBL230533 1 7.70
CHEMBL230532 1 7.44
CHEMBL230634 1 7.27
CHEMBL390857 1 7.22
CHEMBL37541 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL230744 IC50 = 1.0 nM 9.00
CHEMBL230743 IC50 = 2.0 nM 8.70
CHEMBL230744 IC50 = 3.0 nM 8.52
CHEMBL230744 IC50 = 3.0 nM 8.52
CHEMBL230635 IC50 = 4.0 nM 8.40
CHEMBL390856 IC50 = 15.0 nM 7.82
CHEMBL397464 IC50 = 17.0 nM 7.77
CHEMBL230533 IC50 = 20.0 nM 7.70
CHEMBL230532 IC50 = 36.0 nM 7.44
CHEMBL230634 IC50 = 54.0 nM 7.27
CHEMBL390857 IC50 = 60.0 nM 7.22
CHEMBL37541 IC50 = 930.0 nM 6.03