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Assay Detail

CHEMBL894268

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Functional
Antiviral activity against Hepatitis C virus infected Huh7 cells
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones.
Li H, Linton A, Tatlock J, Gonzalez J, Borchardt A, Abreo M, Jewell T, Patel L, Drowns M, Ludlum S, Goble M, Yang M, Blazel J, Rahavendran R, Skor H, Shi S, Lewis C, Fuhrman S.
J Med Chem (2007) 50 : 3969 -3972
PubMed 17658778 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.72 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL230744 3 7.82
CHEMBL230743 1 7.13
CHEMBL397464 1 6.96
CHEMBL230635 1 6.50
CHEMBL230533 1 6.48
CHEMBL390856 1 6.40
CHEMBL390857 1 6.21
CHEMBL230634 1 5.92
CHEMBL230532 1 5.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL230744 EC50 = 15.0 nM 7.82
CHEMBL230744 EC50 = 30.0 nM 7.52
CHEMBL230744 EC50 = 32.0 nM 7.50
CHEMBL230743 EC50 = 74.0 nM 7.13
CHEMBL397464 EC50 = 110.0 nM 6.96
CHEMBL230635 EC50 = 320.0 nM 6.50
CHEMBL230533 EC50 = 330.0 nM 6.48
CHEMBL390856 EC50 = 400.0 nM 6.40
CHEMBL390857 EC50 = 610.0 nM 6.21
CHEMBL230634 EC50 = 1200.0 nM 5.92
CHEMBL230532 EC50 = 3250.0 nM 5.49