Assay Detail
Binding
CHEMBL894310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 NL4-3 reverse transcriptase
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.82 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292923 | — | — | 1 | 8.14 |
| CHEMBL58581 | — | — | 1 | 6.96 |
| CHEMBL293984 | — | — | 1 | 6.55 |
| CHEMBL58494 | — | — | 1 | 6.50 |
| CHEMBL61352 | — | — | 1 | 5.79 |
| CHEMBL58268 | — | — | 1 | 5.73 |
| CHEMBL291505 | — | — | 1 | 5.58 |
| CHEMBL294604 | — | — | 1 | 5.31 |
| CHEMBL418637 | — | — | 1 | 4.76 |
| CHEMBL244144 | — | — | 1 | 4.40 |
| CHEMBL58358 | — | — | 1 | 4.26 |
| CHEMBL58007 | — | — | 1 | - |
| CHEMBL388694 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL56435 | — | — | 1 | - |
| CHEMBL413932 | — | — | 1 | - |
| CHEMBL231567 | — | — | 1 | - |
| CHEMBL389119 | — | — | 1 | - |
| CHEMBL59448 | — | — | 1 | - |
| CHEMBL293961 | — | — | 1 | - |
| CHEMBL292138 | — | — | 1 | - |
| CHEMBL397900 | — | — | 1 | - |
| CHEMBL244357 | — | — | 1 | - |
| CHEMBL244358 | — | — | 1 | - |
| CHEMBL231566 | — | — | 1 | - |
| CHEMBL292831 | — | — | 1 | - |
| CHEMBL244145 | — | — | 1 | - |
| CHEMBL59237 | — | — | 1 | - |
| CHEMBL294004 | — | — | 1 | - |
| CHEMBL57770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292923 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL58581 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL293984 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL58494 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL61352 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL58268 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL291505 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL294604 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL418637 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL244144 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL58358 | — | IC50 | = | 54700.0 | nM | 4.26 |
| CHEMBL244143 | — | IC50 | - | — | - | |
| CHEMBL388693 | — | IC50 | = | 157800.0 | nM | - |
| CHEMBL58007 | — | IC50 | - | — | - | |
| CHEMBL388694 | — | IC50 | - | — | - | |
| CHEMBL57 | NEVIRAPINE | IC50 | - | — | - | |
| CHEMBL56435 | — | IC50 | - | — | - | |
| CHEMBL413932 | — | IC50 | - | — | - | |
| CHEMBL231567 | — | IC50 | - | — | - | |
| CHEMBL389119 | — | IC50 | - | — | - | |
| CHEMBL59448 | — | IC50 | - | — | - | |
| CHEMBL293961 | — | IC50 | = | 200.0 | nM | - |
| CHEMBL292138 | — | IC50 | - | — | - | |
| CHEMBL397900 | — | IC50 | - | — | - | |
| CHEMBL244357 | — | IC50 | - | — | - | |
| CHEMBL244358 | — | IC50 | - | — | - | |
| CHEMBL231566 | — | IC50 | - | — | - | |
| CHEMBL292831 | — | IC50 | - | — | - | |
| CHEMBL244145 | — | IC50 | - | — | - | |
| CHEMBL59237 | — | IC50 | - | — | - | |
| CHEMBL294004 | — | IC50 | - | — | - | |
| CHEMBL57770 | — | IC50 | - | — | - |