Assay Detail

CHEMBL894330

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Functional

Inhibition of CXCL8-induced cell migration in L1.2 cells expressing CXCR1 by chemotaxis assay

ChEMBL ↗

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Target

L1.2 (CHEMBL612572) ↗

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L1.2 (CHEMBL612572) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target L1.2

CHEMBL612572

Anchored from Assay target.

Protein identity L1.2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	L1.2
Confidence	1 — Organism
Curated By	Autocuration

Target

L1.2 (CHEMBL612572) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2.

Moriconi A, Cesta MC, Cervellera MN, Aramini A, Coniglio S, Colagioia S, Beccari AR, Bizzarri C, Cavicchia MR, Locati M, Galliera E, Di Benedetto P, Vigilante P, Bertini R, Allegretti M.
J Med Chem (2007) 50 : 3984 -4002
PubMed 17665889 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.25	8.25

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL191413	REPARIXIN	3.0	1	8.25

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL191413	REPARIXIN	IC50	=	5.6	nM	8.25