Assay Detail
Functional
CHEMBL894354
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Hydroxy radical scavenging activity by ESR spin-trapping method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.41 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387129 | — | — | 1 | 7.05 |
| CHEMBL244778 | — | — | 1 | 6.66 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | 6.60 |
| CHEMBL376894 | — | — | 1 | 6.42 |
| CHEMBL373481 | — | — | 1 | 6.21 |
| CHEMBL373456 | — | — | 1 | 6.14 |
| CHEMBL223084 | — | — | 1 | 6.10 |
| CHEMBL223006 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387129 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL244778 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL290916 | EDARAVONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL376894 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL373481 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL373456 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL223084 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL223006 | — | IC50 | = | 810.0 | nM | 6.09 |