Assay Detail
Binding
CHEMBL894469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 from CB1 receptor in rat brain synaptosomal membrane
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.53 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231368 | — | — | 1 | 9.32 |
| CHEMBL231466 | — | — | 1 | 9.14 |
| CHEMBL389118 | — | — | 1 | 9.03 |
| CHEMBL231465 | — | — | 1 | 8.82 |
| CHEMBL231268 | — | — | 1 | 8.82 |
| CHEMBL390404 | — | — | 1 | 8.57 |
| CHEMBL231565 | — | — | 1 | 8.41 |
| CHEMBL67464 | — | — | 1 | 8.06 |
| CHEMBL231369 | — | — | 1 | 8.00 |
| CHEMBL231464 | — | — | 1 | 7.87 |
| CHEMBL231367 | — | — | 1 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231368 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL231466 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL389118 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL231465 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL231268 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL390404 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL231565 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL67464 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL231369 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL231464 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL231367 | — | Ki | = | 18.4 | nM | 7.74 |