Assay Detail
Functional
CHEMBL894701
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Antagonist activity at human brain adrenergic alpha-2 receptor assessed as UK-14304-stimulated [35S]GTPgammaS binding at 10 uM
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.08 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242102 | — | — | 1 | 5.36 |
| CHEMBL1204388 | — | — | 1 | 4.80 |
| CHEMBL243061 | — | — | 1 | - |
| CHEMBL390246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242102 | — | EC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL1204388 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL243061 | — | EC50 | = | 141000.0 | nM | - |
| CHEMBL390246 | — | EC50 | = | 355000.0 | nM | - |