Assay Detail
Binding
CHEMBL894811
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Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.02 | 10.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409969 | — | — | 1 | 10.55 |
| CHEMBL2372052 | — | — | 1 | 10.26 |
| CHEMBL269068 | — | — | 1 | 9.75 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | 9.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409969 | — | Ki | = | 0.02818 | nM | 10.55 |
| CHEMBL2372052 | — | Ki | = | 0.05495 | nM | 10.26 |
| CHEMBL269068 | — | Ki | = | 0.1778 | nM | 9.75 |
| CHEMBL396460 | NOCICEPTIN | Ki | = | 0.3162 | nM | 9.50 |