Assay Detail
Binding
CHEMBL894814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human recombinant kappa opioid receptor expressed in in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.00 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | — | 1 | 9.90 |
| CHEMBL409969 | — | — | 1 | 8.36 |
| CHEMBL2372052 | — | — | 1 | 7.55 |
| CHEMBL269068 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL409969 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL2372052 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL269068 | — | Ki | = | 676.08 | nM | 6.17 |