Assay Detail
Functional
CHEMBL894820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at NOP receptor in Albino guinea pig ileum assessed as effect on electrically stimulated contractions
5
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.61 | 9.17 |
| Emax | 2 | - | - |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409969 | — | — | 2 | 9.17 |
| CHEMBL396460 | NOCICEPTIN | — | 2 | 8.05 |
| CHEMBL269068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409969 | — | EC50 | = | 0.6761 | nM | 9.17 |
| CHEMBL396460 | NOCICEPTIN | EC50 | = | 8.913 | nM | 8.05 |
| CHEMBL396460 | NOCICEPTIN | Emax | = | 45.0 | % | - |
| CHEMBL269068 | — | Activity | - | — | - | |
| CHEMBL409969 | — | Emax | = | 32.0 | % | - |