Assay Detail
Functional
CHEMBL894822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at NOP receptor in Sprague-Dawley rat vas deferens assessed as effect on electrically stimulated contractions
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pA2 | 2 | - | - |
| Kd | 2 | 8.14 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372052 | — | — | 1 | 9.22 |
| CHEMBL269068 | — | — | 1 | 7.06 |
| CHEMBL396460 | NOCICEPTIN | — | 1 | - |
| CHEMBL409969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372052 | — | Kd | = | 0.6026 | nM | 9.22 |
| CHEMBL269068 | — | Kd | = | 87.1 | nM | 7.06 |
| CHEMBL396460 | NOCICEPTIN | pA2 | - | — | - | |
| CHEMBL409969 | — | pA2 | - | — | - |