Assay Detail
Binding
CHEMBL894930
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Inhibition of human recombinant soluble epoxide hydrolase
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Orally bioavailable potent soluble epoxide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 8.41 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244192 | — | — | 1 | 9.26 |
| CHEMBL244002 | — | — | 1 | 9.22 |
| CHEMBL397694 | — | — | 1 | 9.19 |
| CHEMBL244193 | — | — | 1 | 9.14 |
| CHEMBL243335 | — | — | 1 | 9.10 |
| CHEMBL396546 | — | — | 1 | 9.09 |
| CHEMBL427695 | — | — | 1 | 9.06 |
| CHEMBL242898 | — | — | 1 | 9.05 |
| CHEMBL244405 | — | — | 1 | 9.05 |
| CHEMBL221014 | — | — | 1 | 9.05 |
| CHEMBL243793 | — | — | 1 | 9.05 |
| CHEMBL243336 | — | — | 1 | 9.00 |
| CHEMBL374322 | — | — | 1 | 9.00 |
| CHEMBL395738 | — | — | 1 | 8.96 |
| CHEMBL242459 | — | — | 1 | 8.89 |
| CHEMBL243337 | — | — | 1 | 8.89 |
| CHEMBL242025 | — | — | 1 | 8.82 |
| CHEMBL242255 | — | — | 1 | 8.80 |
| CHEMBL395989 | — | — | 1 | 8.80 |
| CHEMBL243124 | — | — | 1 | 8.77 |
| CHEMBL376647 | — | — | 1 | 8.77 |
| CHEMBL242899 | — | — | 1 | 8.77 |
| CHEMBL395988 | — | — | 1 | 8.77 |
| CHEMBL244406 | — | — | 1 | 8.72 |
| CHEMBL243125 | — | — | 1 | 8.70 |
| CHEMBL245255 | — | — | 1 | 8.70 |
| CHEMBL242460 | — | — | 1 | 8.68 |
| CHEMBL395987 | — | — | 1 | 8.60 |
| CHEMBL243522 | — | — | 1 | 8.60 |
| CHEMBL242256 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244192 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL244002 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL397694 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL244193 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL243335 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL396546 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL427695 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL242898 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL244405 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL221014 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL243793 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL243336 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL374322 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL395738 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL243337 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL242459 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL242025 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL242255 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL395989 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL243124 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL376647 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL242899 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL395988 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL244406 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL243125 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL245255 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL242460 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL395987 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL243522 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL242256 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL388015 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL242900 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL397426 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL397693 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL242026 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL245225 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL387810 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL397669 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL242470 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL243302 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL395714 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL243521 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1458 | 1,3-DICYCLOHEXYLUREA | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL242257 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL397197 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL222160 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL244407 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL231584 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL245006 | — | IC50 | = | 8300.0 | nM | 5.08 |