Assay Detail

CHEMBL894936

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of hamster soluble epoxide hydrolase by radioactive assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cricetinae
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Orally bioavailable potent soluble epoxide hydrolase inhibitors.

Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD.
J Med Chem (2007) 50 : 3825 -3840
PubMed 17616115 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	4	8.60	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL436774	AR9281	2.0	1	8.70
CHEMBL242655	—	—	1	8.70
CHEMBL242459	—	—	1	8.70
CHEMBL215387	—	—	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL436774	AR9281	IC50	=	2.0	nM	8.70
CHEMBL242655	—	IC50	=	2.0	nM	8.70
CHEMBL242459	—	IC50	=	2.0	nM	8.70
CHEMBL215387	—	IC50	=	5.0	nM	8.30