Assay Detail
Binding
CHEMBL894947
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Inhibition of VZV thymidine kinase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Thymidine kinase (CHEMBL4784) ↗| Type | SINGLE PROTEIN |
| Organism | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Publication
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.86 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397671 | — | — | 1 | 5.54 |
| CHEMBL244824 | — | — | 1 | 5.43 |
| CHEMBL244615 | — | — | 1 | 5.38 |
| CHEMBL396223 | — | — | 1 | 4.82 |
| CHEMBL244825 | — | — | 1 | 4.75 |
| CHEMBL245043 | — | — | 1 | 4.62 |
| CHEMBL244826 | — | — | 1 | 4.52 |
| CHEMBL244614 | — | — | 1 | 4.47 |
| CHEMBL243987 | — | — | 1 | 4.19 |
| CHEMBL244409 | — | — | 1 | - |
| CHEMBL244194 | — | — | 1 | - |
| CHEMBL243988 | — | — | 1 | - |
| CHEMBL144817 | — | — | 1 | - |
| CHEMBL201494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397671 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL244824 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL244615 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL396223 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL244825 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL245043 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL244826 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL244614 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL243987 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL244409 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL244194 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL243988 | — | IC50 | = | 493000.0 | nM | - |
| CHEMBL144817 | — | IC50 | >= | 500000.0 | nM | - |
| CHEMBL201494 | — | IC50 | = | 217000.0 | nM | - |