Assay Detail
Functional
CHEMBL894956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.16 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.30 |
| CHEMBL244176 | — | — | 1 | 6.24 |
| CHEMBL244593 | — | — | 1 | 5.45 |
| CHEMBL245238 | — | — | 1 | 5.30 |
| CHEMBL245015 | — | — | 1 | 5.30 |
| CHEMBL245016 | — | — | 1 | 5.17 |
| CHEMBL414890 | PROTOAPIGENONE | — | 1 | 5.09 |
| CHEMBL244803 | — | — | 1 | 5.00 |
| CHEMBL397013 | — | — | 1 | 4.84 |
| CHEMBL397277 | — | — | 1 | 4.81 |
| CHEMBL245239 | — | — | 1 | 4.57 |
| CHEMBL394770 | — | — | 1 | 4.57 |
| CHEMBL396471 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL244176 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL244593 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL245238 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL245015 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL245016 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL414890 | PROTOAPIGENONE | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL244803 | — | IC50 | = | 9940.0 | nM | 5.00 |
| CHEMBL397013 | — | IC50 | = | 14370.0 | nM | 4.84 |
| CHEMBL397277 | — | IC50 | = | 15580.0 | nM | 4.81 |
| CHEMBL245239 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL394770 | — | IC50 | = | 27010.0 | nM | 4.57 |
| CHEMBL396471 | — | IC50 | = | 40860.0 | nM | 4.39 |