Assay Detail
Functional
CHEMBL894958
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.00 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.85 |
| CHEMBL244593 | — | — | 1 | 6.41 |
| CHEMBL244176 | — | — | 1 | 6.37 |
| CHEMBL245015 | — | — | 1 | 6.27 |
| CHEMBL245238 | — | — | 1 | 6.17 |
| CHEMBL245016 | — | — | 1 | 6.15 |
| CHEMBL397013 | — | — | 1 | 5.97 |
| CHEMBL244803 | — | — | 1 | 5.94 |
| CHEMBL414890 | PROTOAPIGENONE | — | 1 | 5.84 |
| CHEMBL397277 | — | — | 1 | 5.76 |
| CHEMBL245239 | — | — | 1 | 5.72 |
| CHEMBL394770 | — | — | 1 | 5.33 |
| CHEMBL396471 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL244593 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL244176 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL245015 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL245238 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL245016 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL397013 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL244803 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL414890 | PROTOAPIGENONE | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL397277 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL245239 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL394770 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL396471 | — | IC50 | = | 5490.0 | nM | 5.26 |