Assay Detail
Functional
CHEMBL894959
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.60 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244593 | — | — | 1 | 6.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.13 |
| CHEMBL245015 | — | — | 1 | 5.92 |
| CHEMBL244176 | — | — | 1 | 5.77 |
| CHEMBL245016 | — | — | 1 | 5.76 |
| CHEMBL244803 | — | — | 1 | 5.57 |
| CHEMBL397013 | — | — | 1 | 5.53 |
| CHEMBL245238 | — | — | 1 | 5.46 |
| CHEMBL414890 | PROTOAPIGENONE | — | 1 | 5.43 |
| CHEMBL394770 | — | — | 1 | 5.38 |
| CHEMBL397277 | — | — | 1 | 5.28 |
| CHEMBL245239 | — | — | 1 | 5.26 |
| CHEMBL396471 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244593 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL245015 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL244176 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL245016 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL244803 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL397013 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL245238 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL414890 | PROTOAPIGENONE | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL394770 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL397277 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL245239 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL396471 | — | IC50 | = | 7990.0 | nM | 5.10 |