Assay Detail
Binding
CHEMBL895077
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Displacement of [3H]RX 821002 from human adrenergic alpha2A receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.20 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223836 | — | — | 1 | 7.83 |
| CHEMBL374584 | — | — | 1 | 7.56 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 7.32 |
| CHEMBL222928 | — | — | 1 | 7.22 |
| CHEMBL397753 | — | — | 1 | 7.14 |
| CHEMBL242693 | — | — | 1 | 7.09 |
| CHEMBL396013 | — | — | 1 | 7.04 |
| CHEMBL373535 | — | — | 1 | 6.86 |
| CHEMBL242265 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223836 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL374584 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL128168 | BIPHENYLINE | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL222928 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL397753 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL242693 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL396013 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL373535 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL242265 | — | Ki | = | 186.21 | nM | 6.73 |