Assay Detail
Binding
CHEMBL895093
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Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.11 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 9.11 |
| CHEMBL244403 | — | — | 1 | 7.82 |
| CHEMBL390675 | — | — | 1 | 7.60 |
| CHEMBL244402 | — | — | 1 | 7.32 |
| CHEMBL188 | WIN-552122 | — | 1 | 6.85 |
| CHEMBL244606 | — | — | 1 | 6.80 |
| CHEMBL243334 | — | — | 1 | 6.52 |
| CHEMBL244607 | — | — | 1 | 6.03 |
| CHEMBL244189 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL244403 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL390675 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL244402 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL188 | WIN-552122 | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL244606 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL243334 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL244607 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL244189 | — | IC50 | = | 1100.0 | nM | 5.96 |