Assay Detail
Binding
CHEMBL895159
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Inhibition of KSP D130V mutant by ATPase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel ATP-competitive kinesin spindle protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.45 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243669 | — | — | 1 | 8.22 |
| CHEMBL390629 | — | — | 1 | 8.15 |
| CHEMBL244933 | — | — | 1 | 6.96 |
| CHEMBL436624 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243669 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL390629 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL244933 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL436624 | — | Ki | = | 350.0 | nM | 6.46 |