Assay Detail
Binding
CHEMBL895180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.25 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226735 | — | — | 1 | 7.70 |
| CHEMBL294840 | — | — | 1 | 6.52 |
| CHEMBL107200 | — | — | 1 | 6.52 |
| CHEMBL243068 | — | — | 1 | 6.41 |
| CHEMBL231473 | — | — | 1 | 6.35 |
| CHEMBL387567 | — | — | 1 | 6.33 |
| CHEMBL231274 | — | — | 1 | 6.28 |
| CHEMBL244780 | — | — | 1 | 6.05 |
| CHEMBL231470 | — | — | 1 | 6.04 |
| CHEMBL243277 | — | — | 1 | 6.00 |
| CHEMBL244781 | — | — | 1 | 5.58 |
| CHEMBL231275 | — | — | 1 | 5.50 |
| CHEMBL387804 | — | — | 1 | 5.28 |
| CHEMBL244999 | — | — | 1 | 5.20 |
| CHEMBL231072 | — | — | 1 | 5.17 |
| CHEMBL243067 | — | — | 1 | 5.13 |
| CHEMBL231377 | — | — | 1 | 5.11 |
| CHEMBL245218 | — | — | 1 | 5.11 |
| CHEMBL242843 | — | — | 1 | 5.11 |
| CHEMBL438127 | — | — | 1 | 5.04 |
| CHEMBL244998 | — | — | 1 | 5.03 |
| CHEMBL243066 | — | — | 1 | 4.62 |
| CHEMBL555376 | — | — | 1 | 4.54 |
| CHEMBL242845 | — | — | 1 | 4.50 |
| CHEMBL398201 | — | — | 1 | 4.48 |
| CHEMBL231375 | — | — | 1 | 4.44 |
| CHEMBL230966 | — | — | 1 | 4.32 |
| CHEMBL3706913 | — | — | 1 | 4.28 |
| CHEMBL398202 | — | — | 1 | 4.26 |
| CHEMBL255525 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226735 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL294840 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL107200 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL243068 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL231473 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL387567 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL231274 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL244780 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL231470 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL243277 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL244781 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL231275 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL387804 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL244999 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL231072 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL243067 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL231377 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL245218 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL242843 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL438127 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL244998 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL243066 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL555376 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL242845 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL398201 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL231375 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL230966 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3706913 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL398202 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL255525 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL242844 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL396233 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3706914 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL429286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL231175 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL231376 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241996 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | IC50 | - | — | - | |
| CHEMBL223228 | EFAVIRENZ | IC50 | - | — | - |