Assay Detail
Binding
CHEMBL895226
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Inhibition of rat brain mitochondria MAOA by radioenzymatic assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.41 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348597 | — | — | 1 | 5.07 |
| CHEMBL396267 | — | — | 1 | 4.91 |
| CHEMBL231583 | — | — | 1 | 4.87 |
| CHEMBL242409 | — | — | 1 | 4.67 |
| CHEMBL243081 | — | — | 1 | 4.47 |
| CHEMBL156994 | — | — | 1 | 4.43 |
| CHEMBL82327 | — | — | 1 | 4.38 |
| CHEMBL243512 | — | — | 1 | 4.35 |
| CHEMBL243733 | — | — | 1 | 4.30 |
| CHEMBL242835 | — | — | 1 | 4.14 |
| CHEMBL394347 | — | — | 1 | 4.07 |
| CHEMBL243058 | — | — | 1 | 4.05 |
| CHEMBL244771 | — | — | 1 | 4.00 |
| CHEMBL243059 | — | — | 1 | 4.00 |
| CHEMBL352004 | — | — | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL242618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348597 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL396267 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL231583 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL242409 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL243081 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL156994 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL82327 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL243512 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL243733 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL242835 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL394347 | — | IC50 | = | 84600.0 | nM | 4.07 |
| CHEMBL243058 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL244771 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL243059 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL352004 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 580000.0 | nM | - |
| CHEMBL242618 | — | IC50 | = | 114000.0 | nM | - |