Assay Detail
Binding
CHEMBL895324
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Inhibition of wild type human PNMT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.19 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59441 | — | — | 1 | 7.77 |
| CHEMBL177621 | — | — | 1 | 7.46 |
| CHEMBL176112 | — | — | 1 | 7.41 |
| CHEMBL290890 | — | — | 1 | 7.34 |
| CHEMBL286497 | — | — | 1 | 6.68 |
| CHEMBL355581 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59441 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL177621 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL176112 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL290890 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL286497 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL355581 | — | Ki | = | 315.0 | nM | 6.50 |