Assay Detail
Binding
CHEMBL895325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PNMT K57A mutant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phenylethanolamine N-methyltransferase (CHEMBL4617) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.99 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290890 | — | — | 1 | 9.00 |
| CHEMBL286497 | — | — | 1 | 8.89 |
| CHEMBL176112 | — | — | 1 | 8.85 |
| CHEMBL355581 | — | — | 1 | 8.74 |
| CHEMBL177621 | — | — | 1 | 7.77 |
| CHEMBL59441 | — | — | 1 | 6.84 |
| CHEMBL281289 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290890 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL286497 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL176112 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL355581 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL177621 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL59441 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL281289 | — | Ki | = | 1370.0 | nM | 5.86 |