Assay Detail
Binding
CHEMBL895353
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Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.59 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394602 | — | — | 1 | 10.49 |
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 9.46 |
| CHEMBL419667 | RELCOVAPTAN | 2.0 | 1 | 8.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394602 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL373742 | VASOPRESSIN | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL419667 | RELCOVAPTAN | Ki | = | 1.48 | nM | 8.83 |