Assay Detail
Binding
CHEMBL895377
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Inhibition of human NE
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.40 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243437 | — | — | 1 | 8.22 |
| CHEMBL387576 | — | — | 1 | 7.82 |
| CHEMBL430193 | — | — | 1 | 7.68 |
| CHEMBL244726 | — | — | 1 | 7.62 |
| CHEMBL387791 | — | — | 1 | 7.62 |
| CHEMBL244939 | — | — | 1 | 7.55 |
| CHEMBL244908 | — | — | 1 | 7.47 |
| CHEMBL388239 | — | — | 1 | 7.41 |
| CHEMBL244909 | — | — | 1 | 7.35 |
| CHEMBL244940 | — | — | 1 | 7.34 |
| CHEMBL244072 | — | — | 1 | 7.19 |
| CHEMBL244917 | — | — | 1 | 6.98 |
| CHEMBL398167 | — | — | 1 | 6.97 |
| CHEMBL244918 | — | — | 1 | 6.96 |
| CHEMBL396796 | — | — | 1 | 6.64 |
| CHEMBL397270 | — | — | 1 | 6.60 |
| CHEMBL244919 | — | — | 1 | 6.54 |
| CHEMBL245163 | — | — | 1 | 6.52 |
| CHEMBL245164 | — | — | 1 | 6.52 |
| CHEMBL244920 | — | — | 1 | 6.09 |
| CHEMBL243418 | — | — | 1 | 6.00 |
| CHEMBL398168 | — | — | 1 | 5.96 |
| CHEMBL242392 | — | — | 1 | 5.80 |
| CHEMBL244921 | — | — | 1 | 5.60 |
| CHEMBL389383 | — | — | 1 | 5.51 |
| CHEMBL243419 | — | — | 1 | 5.47 |
| CHEMBL243420 | — | — | 1 | 5.14 |
| CHEMBL243422 | — | — | 1 | 5.05 |
| CHEMBL243421 | — | — | 1 | 5.05 |
| CHEMBL243638 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243437 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL387576 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL430193 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL244726 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL387791 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL244939 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL244908 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL388239 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL244909 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL244940 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL244072 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL244917 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL398167 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL244918 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL396796 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL397270 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL244919 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL245163 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL245164 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL244920 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL243418 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL398168 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL242392 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL244921 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL389383 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL243419 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL243420 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL243422 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL243421 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL243638 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL242358 | — | Ki | = | 24500.0 | nM | 4.61 |
| CHEMBL242998 | — | Ki | = | 29900.0 | nM | 4.52 |
| CHEMBL243645 | — | Ki | = | 50900.0 | nM | 4.29 |