Assay Detail
Functional
CHEMBL895651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.72 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244774 | — | — | 1 | 7.64 |
| CHEMBL244562 | — | — | 1 | 7.39 |
| CHEMBL180010 | — | — | 1 | 7.09 |
| CHEMBL390253 | — | — | 1 | 7.05 |
| CHEMBL241973 | — | — | 1 | 6.97 |
| CHEMBL394541 | — | — | 1 | 6.76 |
| CHEMBL244989 | — | — | 1 | 6.75 |
| CHEMBL110365 | — | — | 1 | 6.65 |
| CHEMBL244773 | — | — | 1 | 6.43 |
| CHEMBL231156 | — | — | 1 | 6.17 |
| CHEMBL300780 | — | — | 1 | 5.89 |
| CHEMBL398175 | — | — | 1 | 5.89 |
| CHEMBL304605 | — | — | 1 | - |
| CHEMBL396024 | — | — | 1 | - |
| CHEMBL242644 | — | — | 1 | - |
| CHEMBL242434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244774 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL244562 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL180010 | — | IC50 | = | 80.9 | nM | 7.09 |
| CHEMBL390253 | — | IC50 | = | 88.3 | nM | 7.05 |
| CHEMBL241973 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL394541 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL244989 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL110365 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL244773 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL231156 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL300780 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL398175 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL304605 | — | IC50 | - | — | - | |
| CHEMBL396024 | — | IC50 | - | — | - | |
| CHEMBL242644 | — | IC50 | - | — | - | |
| CHEMBL242434 | — | IC50 | - | — | - |