Assay Detail
Functional
CHEMBL895696
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Antagonist activity at human P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current by two electrode voltage clamping technique
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.35 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238310 | — | — | 1 | 7.84 |
| CHEMBL395723 | — | — | 1 | 7.49 |
| CHEMBL397926 | — | — | 1 | 7.08 |
| CHEMBL69727 | ISOPPADS | — | 1 | 6.97 |
| CHEMBL395493 | SPINORPHIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238310 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL395723 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL397926 | — | IC50 | = | 82.4 | nM | 7.08 |
| CHEMBL69727 | ISOPPADS | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL395493 | SPINORPHIN | IC50 | = | 0.0083 | nM | - |