Assay Detail
Binding
CHEMBL895724
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Displacement of [3H]spiperone from human dopamine D2L receptor expressed in HEK293 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.64 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389357 | — | — | 1 | 7.60 |
| CHEMBL394779 | — | — | 1 | 7.20 |
| CHEMBL231070 | — | — | 1 | 7.13 |
| CHEMBL276778 | — | — | 1 | 7.06 |
| CHEMBL231171 | — | — | 1 | 6.76 |
| CHEMBL389559 | — | — | 1 | 6.42 |
| CHEMBL389356 | — | — | 1 | 6.29 |
| CHEMBL396950 | — | — | 1 | 6.07 |
| CHEMBL397207 | — | — | 1 | 5.99 |
| CHEMBL231374 | — | — | 1 | 5.86 |
| CHEMBL394777 | — | — | 1 | - |
| CHEMBL397180 | — | — | 1 | - |
| CHEMBL443843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389357 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL394779 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL231070 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL276778 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL231171 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL389559 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL389356 | — | Ki | = | 518.0 | nM | 6.29 |
| CHEMBL396950 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL397207 | — | Ki | = | 1028.0 | nM | 5.99 |
| CHEMBL231374 | — | Ki | = | 1396.0 | nM | 5.86 |
| CHEMBL394777 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL397180 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL443843 | — | Ki | > | 10000.0 | nM | - |