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Assay Detail

CHEMBL895727

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(1B) dopamine receptor (CHEMBL1850)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.
Enzensperger C, Müller FK, Schmalwasser B, Wiecha P, Traber H, Lehmann J.
J Med Chem (2007) 50 : 4528 -4533
PubMed 17676831 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.40 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL201170 1 8.82
CHEMBL276778 1 8.34
CHEMBL231070 1 8.01
CHEMBL389356 1 7.77
CHEMBL231171 1 7.28
CHEMBL380330 1 7.27
CHEMBL389357 1 7.26
CHEMBL394779 1 7.16
CHEMBL231374 1 7.12
CHEMBL389559 1 7.02
CHEMBL396950 1 6.50
CHEMBL397207 1 6.29
CHEMBL394777 1 -
CHEMBL397180 1 -
CHEMBL443843 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL201170 Ki = 1.5 nM 8.82
CHEMBL276778 Ki = 4.6 nM 8.34
CHEMBL231070 Ki = 9.8 nM 8.01
CHEMBL389356 Ki = 17.0 nM 7.77
CHEMBL231171 Ki = 53.0 nM 7.28
CHEMBL380330 Ki = 54.0 nM 7.27
CHEMBL389357 Ki = 55.0 nM 7.26
CHEMBL394779 Ki = 69.0 nM 7.16
CHEMBL231374 Ki = 75.0 nM 7.12
CHEMBL389559 Ki = 95.0 nM 7.02
CHEMBL396950 Ki = 314.0 nM 6.50
CHEMBL397207 Ki = 510.0 nM 6.29
CHEMBL394777 Ki > 10000.0 nM -
CHEMBL397180 Ki > 10000.0 nM -
CHEMBL443843 Ki > 10000.0 nM -