Assay Detail
Functional
CHEMBL895740
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Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4- and 5-aroylindoles as novel classes of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.54 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230741 | — | — | 1 | 7.98 |
| CHEMBL395786 | — | — | 1 | 7.65 |
| CHEMBL230846 | — | — | 1 | 7.50 |
| CHEMBL230747 | — | — | 1 | 7.47 |
| CHEMBL230738 | — | — | 1 | 7.33 |
| CHEMBL395785 | — | — | 1 | 7.00 |
| CHEMBL230740 | — | — | 1 | 6.60 |
| CHEMBL230739 | — | — | 1 | 6.48 |
| CHEMBL394805 | — | — | 1 | 6.34 |
| CHEMBL397485 | — | — | 1 | 6.00 |
| CHEMBL442068 | — | — | 1 | 5.92 |
| CHEMBL139194 | — | — | 1 | 5.77 |
| CHEMBL230847 | — | — | 1 | 5.75 |
| CHEMBL230651 | — | — | 1 | 5.34 |
| CHEMBL396257 | — | — | 1 | 5.02 |
| CHEMBL395036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230741 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL395786 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL230846 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL230747 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL230738 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL395785 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL230740 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL230739 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL394805 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL397485 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL442068 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL139194 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL230847 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL230651 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL396257 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL395036 | — | IC50 | > | 10000.0 | nM | - |