Assay Detail
Binding
CHEMBL895787
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Inhibition of HDAC in HeLa cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.69 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390907 | — | — | 1 | 7.47 |
| CHEMBL242533 | — | — | 1 | 7.41 |
| CHEMBL390452 | — | — | 1 | 7.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.16 |
| CHEMBL388429 | — | — | 1 | 7.05 |
| CHEMBL390910 | — | — | 1 | 6.92 |
| CHEMBL244040 | — | — | 1 | 6.58 |
| CHEMBL243181 | — | — | 1 | 6.57 |
| CHEMBL396559 | — | — | 1 | 6.55 |
| CHEMBL390908 | — | — | 1 | 6.51 |
| CHEMBL244885 | — | — | 1 | 6.48 |
| CHEMBL244670 | — | — | 1 | 6.47 |
| CHEMBL243809 | — | — | 1 | 6.35 |
| CHEMBL244887 | — | — | 1 | 6.19 |
| CHEMBL397904 | — | — | 1 | 6.08 |
| CHEMBL395976 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390907 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL242533 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL390452 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL388429 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL390910 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL244040 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL243181 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL396559 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL390908 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL244885 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL244670 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL243809 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL244887 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL397904 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL395976 | — | IC50 | = | 1000.0 | nM | 6.00 |