Assay Detail
Binding
CHEMBL895789
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Inhibition of HDAC in HeLa cells assessed as induction of human histone H3 hyperacetylation
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.57 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390452 | — | — | 1 | 6.54 |
| CHEMBL390907 | — | — | 1 | 6.00 |
| CHEMBL243809 | — | — | 1 | 5.96 |
| CHEMBL242533 | — | — | 1 | 5.89 |
| CHEMBL244885 | — | — | 1 | 5.59 |
| CHEMBL397904 | — | — | 1 | 5.58 |
| CHEMBL388429 | — | — | 1 | 5.57 |
| CHEMBL390910 | — | — | 1 | 5.56 |
| CHEMBL390908 | — | — | 1 | 5.53 |
| CHEMBL244670 | — | — | 1 | 5.42 |
| CHEMBL244887 | — | — | 1 | 5.39 |
| CHEMBL396559 | — | — | 1 | 5.37 |
| CHEMBL243181 | — | — | 1 | 5.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.18 |
| CHEMBL244040 | — | — | 1 | 5.16 |
| CHEMBL395976 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390452 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL390907 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL243809 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL242533 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL244885 | — | EC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL397904 | — | EC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL388429 | — | EC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL390910 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL390908 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL244670 | — | EC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL244887 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL396559 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL243181 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL244040 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL395976 | — | EC50 | = | 7500.0 | nM | 5.12 |