Assay Detail
Functional
CHEMBL895815
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Cytotoxicity against human K562 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.59 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390452 | — | — | 1 | 6.82 |
| CHEMBL242533 | — | — | 1 | 6.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390452 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL242533 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 670.0 | nM | 6.17 |