Assay Detail
Functional
CHEMBL895899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR phosphorylation
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.27 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427837 | — | — | 1 | 9.70 |
| CHEMBL230003 | — | — | 1 | 9.30 |
| CHEMBL389963 | — | — | 1 | 9.30 |
| CHEMBL230107 | — | — | 1 | 9.30 |
| CHEMBL231370 | — | — | 1 | 9.00 |
| CHEMBL230222 | — | — | 1 | 8.80 |
| CHEMBL387591 | — | — | 1 | 8.70 |
| CHEMBL397496 | — | — | 1 | 8.70 |
| CHEMBL231269 | — | — | 1 | 8.70 |
| CHEMBL387590 | — | — | 1 | 8.70 |
| CHEMBL231568 | — | — | 1 | 8.55 |
| CHEMBL397497 | — | — | 1 | 8.52 |
| CHEMBL231168 | — | — | 1 | 8.52 |
| CHEMBL425672 | — | — | 1 | 8.52 |
| CHEMBL230002 | — | — | 1 | 8.52 |
| CHEMBL230223 | — | — | 1 | 8.52 |
| CHEMBL390175 | — | — | 1 | 8.44 |
| CHEMBL413621 | — | — | 1 | 8.41 |
| CHEMBL231570 | — | — | 1 | 8.40 |
| CHEMBL231569 | — | — | 1 | 8.40 |
| CHEMBL231469 | — | — | 1 | 8.40 |
| CHEMBL395335 | — | — | 1 | 8.30 |
| CHEMBL396265 | — | — | 1 | 8.10 |
| CHEMBL394826 | — | — | 1 | 8.05 |
| CHEMBL231067 | — | — | 1 | 8.05 |
| CHEMBL395334 | — | — | 1 | 8.00 |
| CHEMBL425831 | — | — | 1 | 8.00 |
| CHEMBL1162958 | — | — | 1 | 7.92 |
| CHEMBL231371 | — | — | 1 | 7.77 |
| CHEMBL425825 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427837 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL230003 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL389963 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL230107 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL231370 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL230222 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL387591 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL397496 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL231269 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL387590 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL231568 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL230002 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL425672 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL230223 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL231168 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL397497 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL390175 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL413621 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL231570 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL231469 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL231569 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL395335 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL396265 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL394826 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL231067 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL395334 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL425831 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1162958 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL231371 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL425825 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL230109 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL231467 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL427264 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL231468 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL231066 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL231270 | — | Ki | = | 287.0 | nM | 6.54 |