Assay Detail
Binding
CHEMBL895942
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Inhibition of bovine mitochondrial MC1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of the mitochondrial complex 1 inhibitor 2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromene-4-one as a potential cardiac positron emission tomography tracer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.44 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | — | 1 | 8.10 |
| CHEMBL243283 | — | — | 1 | 8.05 |
| CHEMBL243729 | — | — | 1 | 7.82 |
| CHEMBL429100 | — | — | 1 | 7.80 |
| CHEMBL429023 | ROTENONE | — | 1 | 7.80 |
| CHEMBL243284 | — | — | 1 | 7.48 |
| CHEMBL430379 | — | — | 1 | 7.28 |
| CHEMBL356903 | — | — | 1 | 7.28 |
| CHEMBL243075 | — | — | 1 | 7.24 |
| CHEMBL243074 | — | — | 1 | 7.22 |
| CHEMBL243282 | FENAZAQUIN | — | 1 | 7.05 |
| CHEMBL243285 | — | — | 1 | 6.88 |
| CHEMBL243727 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL243283 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL243729 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL429100 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL429023 | ROTENONE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL243284 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL430379 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL356903 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL243075 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL243074 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL243282 | FENAZAQUIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL243285 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL243727 | — | IC50 | = | 197.0 | nM | 6.71 |